by Sayer Ji
A shocking new study finds that glyphosate, the active ingredient in Roundup herbicide, “… may be the most biologically disruptive chemical in our environment,” capable of contributing to a wide range of fatal human diseases.
Glyphosate is the world’s most popular herbicide and is designed to kill all but genetically modified “Roundup Ready” plants, such as GM corn, soy, beet, cottonseed and canola. Over 180 million pounds of the chemical are now applied to US soils each year,[ii] and while agrichemical manufacturers and government regulators have considered it ‘relatively safe,’ an expanding body of biomedical research indicates that it may cause over 30 distinct adverse health effects in exposed populations at far lower concentrations than used in agricultural applications.
The new report, authored by Stephanie Seneff, a research scientist at the Massachusetts Institute of Technology, and Anthony Samsel, a retired science consultant from Arthur D. Little, Inc., brings to the forefront concerns voiced by an outspoken minority that Roundup and related glyphosate herbicide formulations are contributing to diseases as far-ranging as inflammatory bowel disease, anorexia, cystic fibrosis, cancer, Alzheimer’s and Parkinson’s disease, and infertility. In fact, the authors propose that glyphosate, contrary to being essentially nontoxic, “… may be the most biologically disruptive chemical in our environment.”
The researchers identified the inhibition and/or disruption of cytochrome P450 (CYP) enzymes as a hitherto overlooked mechanism of toxicity associated with glyphosate exposure in mammals.
CYP enzymes are essential for detoxifying xenobiotic chemicals from the body. Glyphosate therefore enhances the damaging effects of other food borne chemical residues and environmental toxins.
The researchers also showed how interference with CYP enzymes acts synergistically with disruption of the biosynthesis of aromatic amino acids by gut bacteria (e.g. tryptophan), as well as impairment in serum sulfate transport, a critical biological system for cellular detoxification (e.g. transulfuration pathway which detoxifies metals).
These effect, according to the researchers, can contribute to causing or worsening “… most of the diseases and conditions associated with a Western diet which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease.”
This new report may help to explain why over 30 adverse health effects associated with Roundup herbicide exposure have been identified in the peer-reviewed and published literature so far. The full report in PDF form can be obtained here. Please help us spread this information, as well as our Roundup Toxicity Research and GMO Research pages, by sharing them with other concerned individuals and groups.
[i] Samsel A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy. 2013; 15(4):1416-1463.
This article first appeared at GreenMedInfo. Please visit to access their vast database of articles and the latest information in natural health.
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